Reduced γδ intraepithelial lymphocyte number and motility precede the onset of Crohn’s disease-like ileitis.

SHIP deficiency causes Crohn's disease-like ileitis

BACKGROUND Inflammatory bowel disease (IBD) can arise from genetic mutations that compromise intestinal epithelial cell integrity or immune regulation. SHIP has previously been shown to play a pivotal role in limiting the number of immunoregulatory cells and their function. AIM To determine whether SHIP plays a pivotal role in control of immune tolerance in the gut mucosa. METHODS Gastroint...

Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

OBJECTIVE Obesity causes inflammation and insulin resistance in the vasculature as well as in tissues involved in glucose metabolism such as liver, muscle, and adipose tissue. To investigate the relative susceptibility of vascular tissue to these effects, we determined the time course over which inflammation and insulin resistance develops in various tissues of mice with diet-induced obesity (D...

Whence the intestinal intraepithelial lymphocyte?

O ne of the most widely accepted principles of immunobiology is that lymphocytes with phenotypic and functional properties o f T cells develop from hematopoietic precursors during a requisite period of intrathymic maturation. This developmental stage appears to prepare T cells for their ability to recognize tissue-borne foreign antigens, and to render the peripheral T cell repertoire tolerant t...

Intestinal Intraepithelial Lymphocyte

Pinworm Infestation Mimicking Crohns' Disease

We here report a case of a young man who presented to his general practitioner with diarrhea. Inflammatory bowel disease was suspected and a colonoscopy showed aphthous lesions suggestive of Crohns' disease but biopsies revealed eggs of Enterobius vermicularis. When treated for this parasite, his symptoms were alleviated and a followup colonoscopy revealed a normal colon and distal ileum. Enter...